A Modified Table Lookup Substitution Method for Hiding Data in DNA

Concealing confidential messages within DNA sequences has turned into a well-known research in latest years. This paper presents a modified scheme which is based on the Table Lookup Substitution Method (TLSM) to increase its security. The proposed scheme uses an 8-bit binary coding to transform a reference DNA sequence into a binary format to increase the security of the original TLSM. A comparison between the proposed modified scheme with the existing schemes besides the original TLSM is presented. The results and comparisons have proven the ability of the proposed scheme in balancing among the three critical properties for any DNA steganography scheme: capacity, payload, and BPN. In addition, the cracking probability of the proposed modified scheme is more complex than the original TLSM.