埃及男性2型糖尿病患者幽门螺杆菌性胃炎严重程度与血糖控制的关系

Khaled Aly Abdelaty, A. Shamseya, Marwa Ahmed MeheissenMarwa Ahmed Meheissen Marwa Ibrahim
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摘要

背景:幽门螺杆菌(HP)感染是世界上最常见的感染。它与许多胃肠道和非胃肠道疾病有关。有证据表明幽门螺杆菌感染与糖尿病,特别是2型糖尿病有很强的相关性。目的:本研究旨在探讨幽门螺杆菌诱导的2型糖尿病患者胃炎严重程度与血糖控制的关系。患者与方法:50例2型糖尿病男性患者(平均年龄47.50±6.01岁)在亚历山德里亚大学附属医院消化内科行上消化道内镜检查。其中30例幽门螺杆菌阳性(病例),20例幽门螺杆菌阴性(对照组)。收集所有患者的以下数据:BMI、腰围、CBC、肝酶、尿素、肌酐、血红蛋白A1c水平、空腹血糖。同时获得活检标本,通过快速脲酶试验诊断幽门螺杆菌,并通过更新的悉尼评分评估胃炎的组织病理学严重程度。结果:两组年龄、BMI、ESR、肝酶、肌酐比较差异无统计学意义,而血红蛋白、血小板计数、血尿素比较差异有统计学意义。两组间空腹血糖差异无统计学意义,但糖化血红蛋白差异有统计学意义(p<0.001)。病例组血红蛋白A1C与幽门螺杆菌炎症严重程度有统计学意义(p<0.001)。病例组组织病理标本Hb A1C水平与中性粒细胞浸润、慢性炎症、腺萎缩、肠化生呈正相关。结论:幽门螺杆菌感染和幽门螺杆菌引起的胃炎的严重程度与2型糖尿病患者较高的Hb A1C水平相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relation Between Severity of Helicobacter Pylori Induced Gastritis and Glycemic Control in Egyptian Male Patients with Type-2 Diabetes Mellitus
Background: Helicobacter pylori (HP) infection is the most common infection in the world. It was associated with many gastrointestinal and extra-gastrointestinal diseases. There was evidence of strong association between H.pylori infection and Diabetes Mellitus, especially Type 2 DM. Objectives: The aim of our study was to investigate the relationship between severity of Helicobacter Pylori induced gastritis and glycemic control in patients with type 2 diabetis. Patients and methods: Fifty type 2 diabetic male patients (mean age 47.50 ± 6.01years) were admitted to gastroenterology unit of the Alexandria Main University Hospital for upper gastrointestinal endoscopy. Thirty of them are H.pylori positive (cases) and twenty were H.pylori negative (controls). Following data were collected from all patients: BMI, waist circumference, CBC, liver enzymes, urea, creatinine, Hemoglobin A1c level, fasting blood glucose. Also biopsy specimens were obtained to Diagnose H.pylori by rapid urease test and to assess severity of gastritis histopathologically by Updated Sydney Score. Result: comparison between the two studied groups according to age, BMI, ESR, liver enzymes and creatinine showed no significant difference while hemoglobin, platete count, blood urea showed significant difference between the two groups. Although fasting blood glucose showed no statistically significant difference, Hemoglobin A1c showed significant difference between the two groups (p<0.001). There was a statistically significant relationship between hemoglobin A1C and the severity of H.pylori inflammation in cases group (p<0.001). Levels of Hb A1C were positively correlated with neutrophil infiltration, chronic inflammation, glandular atrophy and intestinal metaplasia in histopathology samples from cases group. Conclusions: Helicobacter Pylori infection and severity of H.pylori induced gastritis correlate with higher levels of Hb A1C in type 2 diabetic patients.
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