Emergence of Multi Drug Resistant Salmonella Typhi as Epidemic Among Lower Sindh Regions Patients of Pakistan

This study was aimed to determine the frequency of multidrug-resistant Salmonella Typhi (S. Typhi) among patients that belong to lower region Sindh. This cross-sectional study was conducted at diagnostic and research laboratory, Hyderabad by evaluating cultures and sensitivity reports collected from different health care centers during one year period (November 2016 to November 2017). Total 92 patients were included in study most of patients were children with mean age of 6.2yrs and male population was predominant (63%). A detailed history and examination was done and blood culture reports were followed for sensitivity and resistance.  Blood culture and sensitivity results showed resistance to ampicillin, cefixime, ceftriaxone, ciprofloxacin, and sulphamethoxazole/trimethoprim in 80.4%, 66.3%, 63%, 63% and 82.6%, in respective order. The highest sensitivity (89.1%) was recorded against meropenem. It was concluded that MDR salmonella infection is prevalent in Sindh, particularly in Hyderabad.