雷公藤抗风湿病作用的网络研究

Haiyang Fang, Tinghong Yang, Yichuan Wang, Weidong Zhang, Yang Ga, J. Zhao, Yi Zhang
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引用次数: 0

摘要

类风湿性关节炎(RA)是一种影响关节的慢性疾病,通常发生在人的手腕、手指和脚上。与fda批准的抗ra药物相比,雷公藤多靶点中药(TCM)具有显著的抗ra作用,但其药理作用尚不清楚。在这项工作中,我们从蛋白网络水平研究了TwHF的治疗机制。首先,收集ra相关基因、FDA批准的抗ra药物的蛋白靶点和TwHF。然后,基于这些信息和资源,我们在FDA批准的抗RA药物靶点网络和KEGG RA通路上绘制了TwHF的蛋白靶点。此外,我们定量分析了TwHF的抗风湿作用,并通过基于网络的抗风湿作用评分将其与FDA批准的抗ra药物进行了比较。我们的研究表明,TwHF可能作为抗风湿药和非甾体抗炎药的联合用药,其抗风湿作用可与抗炎药相媲美。本研究有助于我们从网络系统的角度认识中药黄芪治疗类风湿关节炎的作用,并为中医药理学研究提供新的思路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anti-rheumatic effects of Tripterygium wilfordii Hook F in a network perspective
Rheumatoid arthritis (RA) is a chronic disease that affects the joints, often those in a person's wrists, fingers, and feet. In contrast to FDA-approved anti-RA drugs, Tripterygium wilfordii Hook F (TwHF), a traditional Chinese medicine (TCM), featured as multi-targeting, have been acknowledged with notable anti-RA effects although the pharmacology is unclear. In this work, we investigated the therapeutic mechanisms of TwHF at protein network level. First, RA-associated genes, the protein targets of FDA approved anti-RA drugs and TwHF were collected. Then we mapped the protein targets of TwHF on the drug-target network of FDA approved anti-RA drugs and KEGG RA pathway, based on these information and resources. Furthermore, we quantitatively analyzed the anti-rheumatic effect of TwHF and compared it with those of FDA approved anti-RA drugs by a network based anti-rheumatic effect score. Our study suggests that TwHF may function as a combination of disease-modifying anti-rheumatic drug and non-steroidal anti-inflammatory drug and its anti-rheumatic power could be comparable with that of anti-inflammatory agents. This study may facilitate our understanding of the RA treatment by TwHF from the perspective of network systems and it may suggest new approach for the study of TCM pharmacology.
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