毒性剂量反应实验的联合基因组学和代谢组学分析

2005 IEEE Computational Systems Bioinformatics Conference - Workshops (CSBW'05) Pub Date : 2005-08-08 DOI:10.1109/CSBW.2005.81

G. Jahns, N. DelRaso, Mark P. Westrick, Victor Chan, N. Reo, T. Zacharewski

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引用次数: 0

摘要

一种方法已经实施了分析微阵列和核磁共振光谱数据获得从同一组有毒暴露剂量反应实验。核磁共振光谱还可以跟踪曝光的时间过程。分析包括筛选数据以消除信号不显著的变量，适合实验设计的归一化，主成分分析和使用支持向量机的非线性分类。发现可以检测到亚毒性水平的暴露。

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Joint genomic and metabolomic analysis of toxic dose-response experiments

A methodology has been implemented for analyzing microarray and NMR spectral data obtained from the same set of toxic-exposure dose-response experiments. The NMR spectra additionally track the time course of exposure. Analyses consist of screening the data to eliminate variates with insignificant signal, normalization appropriate to the experimental design, principal components analysis, and nonlinear classification using a support vector machine. It is found that exposure at subtoxic levels can be detected.

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来源期刊

2005 IEEE Computational Systems Bioinformatics Conference - Workshops (CSBW'05)

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