基于三角形柔性机构的弯曲针头细胞微注射装置

Su Yan, Haibo Huang, Liguo Chen, Xiwei Gao, Yaqing Li
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引用次数: 0

摘要

现有的微注射针是弯曲针,但目前大多数细胞注射装置是为直针设计的。此外,现有的显微注射针在破膜时产生较大的横向振动。虽然横向振动也被认为是细胞膜破裂的重要条件,但过大的横向振动会对细胞造成很大的损伤,降低细胞注射的成功率。它在一定程度上与现代生物医学的快速发展形成了矛盾。为此,本文提出了一种基于三角形柔性机构的适用于弯曲针头的微注射针头,可以大大降低细胞注射过程中的横向振动,并在轴向上起到导向作用。也适用于比较流行的注射弯针。仿真结果表明,该微注射针能获得较小的横向振动和较稳定的轴向振动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cell Microinjection Device Suitable for Curved Needle Based on Triangular Flexible Mechanism
Existing microinjection needles are curved needles, but most of the current cell injection devices are designed for straight needles. In addition, the existing microinjection needle causes large lateral vibration when the membrane is broken. Although lateral vibration is also considered as an important condition for cell membrane rupture, large lateral vibration will cause great damage to the cells and reduce the success rate of cell injection. To a certain extent, it has formed a contradiction with the rapid development of modern biomedicine. To this end, this paper proposes a micro-injection needle suitable for curved needles based on a triangular flexible mechanism, which can greatly reduce the lateral vibration during cell injection, and plays a guiding role in axial. It is also suitable for the more popular injection bending needle. Simulation results show that the microinjection needle can obtain less lateral vibration and more stable axial vibration.
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