牙齿作为法医调查的DNA来源

Saisha Nayyer, A. Jaiswal
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引用次数: 0

摘要

牙齿是人体中最具弹性的结构之一,相对于焚烧、浸泡、创伤、肢解和分解而言,因此被用于法医调查。牙齿等骨骼以外的硬组织是DNA的丰富来源。骨骼和牙齿的钙化特性有助于在身体的其他部分在大规模灾难中被破坏或退化时保持它们的保存。牙齿是DNA的主要来源,因为它们特殊的结构和在颌骨中的位置,颌骨比骨骼更能保护DNA。与单根牙齿相比,具有较大牙髓和多根的牙齿含有较多的牙髓细胞和牙骨质。无论采用何种实验室程序或死亡时间,研究表明,臼齿和前臼齿是获得DNA图谱的合适候选者。本文的目的是整理有关从牙齿样本中分离DNA的工具和方法的所有信息,并强调其在法医学中的重要性。本文对牙齿DNA的主要研究进行了文献综述,这些研究涉及将牙齿用于人类身份鉴定等目的,同时概述了近年来这项技术的发展,强调了用于分离和分析牙齿DNA的技术在法医科学中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
TEETH AS A SOURCE OF DNA FOR FORENSIC INVESTIGATION - A REVIEW
Teeth are one of the most resilient structures in the human body, with respect to incineration, immersion, trauma, mutilation, and decomposition, and thus, are used in forensic investigations. Hard tissues like Teeth apart from bones are rich sources of DNA. The calcified nature of bones and teeth helps to keep them preserved when other parts of the body are destroyed or degraded in mass disasters. Teeth are frequently chosen sources of DNA because of their special makeup and location within the jawbone, which offers more protection to DNA than bones. Teeth with larger pulp and multi-root contain many pulp cells and have more tooth cementum, compared to single-root teeth. Regardless of the sort of laboratory process adopted or the time since death, studies have shown that molars and premolars are suitable candidates for obtaining DNA profiles. The aim of this article is to collate all information regarding tools and methodologies pertaining to isolating DNA from tooth samples and highlighting its importance in forensic science. This article puts forth a literature review referring to the main studies on DNA from the tooth that involve the utilization of teeth for purposes like human identification, all the while making an overview of the evolution of this technology in the last years, highlighting the importance of techniques used to isolate and analyse DNA from teeth in forensic sciences.
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