大鼠固定挛缩实验模型的有效性研究

Inter Collegas Pub Date : 2022-10-31 DOI:10.35339/ic.9.2.fkh
V. Fishchenko, A. Khasawneh
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引用次数: 0

摘要

固定挛缩是关节或肢体长期固定后出现的常见并发症。它们是由多种因素引起的,包括肌肉萎缩、关节僵硬和组织粘连。本研究旨在探讨大鼠固定挛缩实验模型的有效性。实验研究对象为21只6月龄非线性雄性白种大鼠。我们采用4周的石膏固定来评估实验大鼠膝关节变化的严重程度。本研究的固定期和后固定期各为4周。每周测量患者的屈伸角度、活动范围和挛缩严重程度。在固定期间,所有实验动物的固定膝关节功能都出现进行性损伤。因此,在固定第4周结束时,固定肢体的屈伸极限与另一侧完整肢体及固定第1周相比均有较高的统计学意义。在固定后(研究第5 - 8周),观察到所研究指标的逐步恢复。固定后的四肢伸展和屈曲指标与初始值有显著差异,但也明显好于固定期结束时的值。在活动范围方面,两肢的该指标明显高于研究第4周时的值,但也明显低于初始值。与对侧肢体、基线和第4周的固定数据相比,固定后的活动受限均有统计学意义。膝关节石膏固定4周的实验模型可以造成持续明显的活动限制,可用于进一步研究各种预防和治疗固定挛缩的方法。关键词:膝关节;固定挛缩;实验;老鼠。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study of the effectiveness of the experimental model of immobilization contractures in rats
Immobilization contractures are a common complication that can arise following prolonged immobilization of a joint or limb. They occur due to a combination of factors, including muscle atrophy, joint stiffness, and tissue adhesions. The aim of the study was to study the effectiveness of the experimental model of immobilization contractures in rats. The experimental study was conducted on 21 non-linear white male rats aged 6 months. We used 4-week plaster immobilization to evaluate the severity of changes in the knee joints of experimental rats. The immobilization and post-immobilization period in our study lasted 4 weeks each. Every week, the angles of extension and flexion, range of motion and severity of contracture were measured. During the period of immobilization, there was a progressive impairment of the function of the immobilized knee joints of all experimental animals. Thus, at the end of the 4th week of immobilization, the limits of flexion and extension on the immobilized limb gained high statistical significance in comparison with both the opposite intact limb and with 1st week of immobilization. In the post-immobilization period (from the 5th to the 8th week of the study), a progressive recovery of the studied indicators was observed. The indicators of extension and flexion of the limbs after immobilization were significantly differed from the initial values, but were also significantly better than the values at the end of the immobilization period. As for the range of motion, this indicator for both limbs was significantly higher than the values at 4th week of the study, but was also significantly lower than the initial values. Limitation of movements after immobilization was statistically significant both when compared with the opposite limb and when compared with baseline and 4th week of immobilization data. Experimental model of 4-weeks plaster immobilization of the knee joint allows to create a persistent pronounced limitation of movements and can be used for further study of various methods of prevention and treatment of immobilization contractures. Keywords: knee joint; immobilization contractures; experiment; rats.
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