2595: A novel bioresorbable/biointegratable/biocompatible dressing for negative pressure wound therapy

2595: A novel bioresorbable/biointegratable/biocompatible dressing for negative pressure wound therapy Kevin Wu, R. Cindass, S. D. Lawson, V. S. Gorantla, and M. R. Davis RESTOR Program, 59 Medical Wing, JBSA Lackland AFB, TX, USA Aims Negative pressure wound therapy (NPWT) aims to improve healing by secondary intention of acute and/ or chronic wounds by dynamic vacuum assisted removal of wound exudate, promoting granulation The standard of care in NPWT uses a polyurethane sponge dressing (PUSD) applied to the wound as a filler to help facilitate vacuum suction The PUSD is non-biodegradable and needs removal every 2–3 days, causing repetitive trauma during wound healing We developed 2 novel bioresorbable/biointegratable/biocompatible sponge-dressing scaffolds (3B-SDS) and evaluated their feasibility and efficacy in optimizing wound healing and limiting need for dressing changes in a pre-clinical porcine NPWT wound model. Methods Ten full thickness wounds were created on 6 swine Four randomly chosen wounds served as controls undergoing wet-to-dry (WTD) dressing changes (2 wounds) and PUSD NPWT (2 wounds) The remaining 6 wounds underwent treatment with the novel 3B-SDSs All wounds were assessed every 3 d until creation of a skin graftable area or until the project end date of 2 months The primary outcome measure was time to skin graftable area Wound planimetry, colorimetry, tensiometry, and histology were secondary outcome metrics. Results This is an ongoing study and end point results will be presented at the meeting We anticipate that the 3BSDSs will achieve faster time to a skin graftable area without the need for repeated dressing changes compared to WTD dressing or the PUSD NPWT. Conclusions The use of 3B-SDSs is anticipated to be superior in terms of time to creation of a skin graftable area compared to PUSD NWPT and WTD dressings. CONTACT Kevin Wu kwu72md@gmail.com © 2016 Kevin Wu, R. Cindass, S. D. Lawson, V. S. Gorantla, and M. R. Davis. Published with license by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. VASCULARIZED COMPOSITE ALLOTRANSPLANTATION 2016, VOL. 3, NOS. 1–2, 52 http://dx.doi.org/10.1080/23723505.2016.1234259