保护性rage片段抑制淀粉样蛋白寡聚化

Institute of information technology Pub Date : 1900-01-01 DOI:10.47501/978-5-6044060-1-4.19

T. D. Volkova, A. Avetisyan, D. Koroev, O. Volpina

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引用次数: 0

摘要

本文讨论了β -淀粉样蛋白参与合成RAGE片段保护作用的机制。结果表明，该肽能够抑制溶液中β -淀粉样蛋白低聚物和原纤维的形成。这证实了肽的保护活性与其抑制β -淀粉样蛋白寡聚化过程的能力有关的假设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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PROTECTIVE RAGE FRAGMENT INHIBITS AMYLOID BETA OLIGOMERIZATION

The article discusses the involvement of beta-amyloid in the mechanism of the protective action of the synthetic RAGE fragment. It was shown that the peptide is able to suppress the formation of oligomers and fibrils of beta-amyloid in solution. This confirms the hypothesis that the protective activity of the peptide is associated with its ability to inhibit the process of oligomerization of beta-amyloid.

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Institute of information technology

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