前段光学相干断层扫描在检测与抗vegf注射相关的眼压预测因子中的作用

Y. S. Andreeva, L. Alharki, A. V. Shelankova, M. Budzinskaya
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引用次数: 0

摘要

目的。利用前段光学相干断层扫描(AS-OCT)确定玻璃体内注射抗vegf药物(IVI)后眼压(IOP)升高的预测因素,并研究多次注射治疗新生血管性年龄相关性黄斑变性(nAMD)时虹膜-晶状体隔膜的变化。IVI前、IVI后1分钟、IVI后30分钟、60分钟和180分钟后用ICare Pro眼压计测量IOP。使用Revo NX层析成像仪(Optopol,波兰)评估前房深度(ACD)、前房角度(ACA)和晶状体厚度。研究在IVI前、第一次IVI后一个月、第三次IVI后一个月、治疗开始一年后进行。静脉注射前测量轴向长度1次。轴向长度与IVI后1分钟IOP升高呈负相关(r=0.65, p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of anterior segment optical coherence tomography in the detection of predictors of ophthalmic hypertension associated with anti-VEGF injections
PURPOSE. To identify the predictors of increased intraocular pressure (IOP) after intravitreal injection (IVI) of an antiVEGF drug using anterior segment optical coherence tomography (AS-OCT), and to study changes in the iris-lens diaphragm produced by multiple injections in the treatment of neovascular form of age-related macular degeneration (nAMD).METHODS. IOP was measured with an ICare Pro tonometer before IVI, 1 minute after IVI, 30 minutes, 60 minutes and 180 minutes later. Anterior chamber depth (ACD), anterior chamber angle (ACA), and lens thickness were assessed using Revo NX tomograph (Optopol, Poland). The study was carried out before IVI, one month after the first IVI, one month after the third IVI, one year after the start of treatment. Axial length was measured once before IVI.RESULTS. An inverse correlation was found between axial length and an increase in IOP 1 min after IVI (r=0.65, p<0.001). According to AS-OCT data, one year after the start of treatment there was a significant decrease in ACD compared to the data before treatment (p><0.001), as well as a decrease in all parameters of ACA (p><0.05). Shorter axial length (R2 =0.45, p><0.05), shorter ACD (R2 =0.44, p><0.05), smaller ACA on the nasal (R2 =0.37, p><0.05) and temporal (R2 =0.39, p><0.05) sides in patients with their own lens led to a greater rise in IOP 1 min after IVI.CONCLUSION. Predictors of a sharp increase in IOP after IVI of an anti-VEGF drug in patients with nAMD that can be detected with AS-OCT are shorter ACD and smaller ACA. The following prognostic model was determined — with a 1-mm decrease in the axial length, an increase in IOP by 2.3 mm Hg should be expected, a decrease in ACA from the temporal side by 1° leads to an increase in IOP of 0.28 mm Hg>
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