提取遗传医学数据信息的机器学习方法

A. Hussain
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引用次数: 4

摘要

生物信息学是生物和生物医学研究数据领域计算工具的开发和应用,除了临床信息学之外,还包括公共卫生信息学和人口信息学。生物信息学代表了一种很有前途的工具集,可以从标准疗法转变为针对每个个体基因组的量身定制医疗护理,因此,他们不是对患有某种疾病的患者群体使用某种疗法,而是针对每个个体基因组定制这种疗法。机器学习算法和技术已被用于生物信息学。有许多方法可用于处理数据,包括DNA序列、复杂的基因-基因相互作用数据和临床数据。为了评估这些复杂的数据,有几种方法,如多因素降维、广义多因素降维、人工神经网络(如多层前馈神经网络)和特征选择方法。这些方法提供了处理包含大量特性的非常大的数据的能力。在这次演讲中,将讨论两个案例研究,其中包括使用机器学习来提取遗传信息,包括肥胖和糖尿病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Machine learning approaches for extracting genetic medical data information
Bioinformatics is the development and application of computational tools for the field of biological and biomedical research data, including public health informatics and population informatics, in addition to clinical informatics. Bioinformatics represents a promising toolset to move from the standard therapies to tailor medical care to each individual genome, therefore instead of using certain therapy to group of patients suffering of certain disease, they tailor this therapy to each individual genome. Machine learning algorithms and techniques have been used in bioinformatics. There are many methods available to deal with data including DNA sequence, complex gene-gene interactions data, and clinical data. To assess these complex data, there are several approaches such as multifactor dimensionality reduction, generalized multifactor dimensionality reduction, artificial neural networks for example multilayer feedforward neural networks, and feature selection approaches. These approaches provide capabilities to deal with very big data that include an excessive number of features. In this talk, two case studies will be discussed for the use of machine learning for extracting genetic information which includes obesity and diabetes.
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