基于智能手机的便携式光学生物传感器,利用表面等离子体共振

C. A. D. S. Filho, A. Lima, H. Neff
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引用次数: 16

摘要

介绍了一种适合未来医学诊断应用的便携式低成本生物传感器。该设备包括一个定制设计的支架、一个用于表面等离子体共振(SPR)传感的一次性聚合物芯片和一个智能手机。该商用电信设备提供触发SPR现象所需的光学照明,并通过其有机发光二极管(即智能手机显示屏)的有源矩阵建立,而光学检测则通过其1.9 Mpx CMOS图像传感器作为前置摄像头获得。这个概念不需要任何额外的光学设备,除了sprr芯片本身和机械支架。所谓的角度询问模式被用于SPR特征的检测。采用适当的数据提取算法,仪器的灵敏度接近10-5 RIU。该值与现有实验室式spr仪器相比较,证实了该技术方法的可行性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Smartphone based, portable optical biosensor utilizing surface plasmon resonance
A portable low cost biosensor suited for future medical diagnostic application is presented. The device comprises a custom designed scaffold, a disposable polymeric chip for surface plasmon resonance (SPR) sensing, and a smartphone. This commercial telecommunication device provides both, the optical illumination required for triggering of the SPR phenomenon and established by its active-matrix of organic light-emitting diodes (i.e., the smartphone display), whereas optical detection is obtained by means of its 1.9 Mpx CMOS image sensor that serves as the front camera. This concept does not require any additional optical device, except the SPR-chip itself and mechanical scaffold. The so-called angular interrogation mode has been employed for detection of the SPR feature. Employing appropriate data extraction algorithms, the sensitivity of the instrument approaches 10-5 RIU. This value compares well with existing laboratory style SPR-instruments, confirming feasibility of this technical approach.
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