{"title":"血栓性微血管病变的多个方面","authors":"Saroshi Amirthalingam","doi":"10.33590/emjhematol/10310448","DOIUrl":null,"url":null,"abstract":"The Alexion satellite symposium was introduced by Prof Pier Mannuccio Mannucci who provided an introduction to the history of thrombotic microangiopathies (TMAs). Prof Paul Coppo gave an overview of TMAs and the differential diagnosis of atypical hemolytic-uraemic syndrome (aHUS) and thrombotic thrombocytopaenic purpura (TTP). He emphasised the importance of a suitable differential diagnosis in order to initiate an appropriate treatment as soon as possible, eventually allowing better patient outcomes. Prof Javier de la Rubia discussed the role of the complement pathway and how genetic abnormalities can lead to dysregulation in aHUS. Prof Thorsten Feldkamp concluded by giving an overview of the latest clinical trial data on the efficacy and safety of eculizumab in the management of aHUS.","PeriodicalId":326555,"journal":{"name":"EMJ Hematology","volume":"102 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2014-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Multiple Facets of Thrombotic Microangiopathies\",\"authors\":\"Saroshi Amirthalingam\",\"doi\":\"10.33590/emjhematol/10310448\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The Alexion satellite symposium was introduced by Prof Pier Mannuccio Mannucci who provided an introduction to the history of thrombotic microangiopathies (TMAs). Prof Paul Coppo gave an overview of TMAs and the differential diagnosis of atypical hemolytic-uraemic syndrome (aHUS) and thrombotic thrombocytopaenic purpura (TTP). He emphasised the importance of a suitable differential diagnosis in order to initiate an appropriate treatment as soon as possible, eventually allowing better patient outcomes. Prof Javier de la Rubia discussed the role of the complement pathway and how genetic abnormalities can lead to dysregulation in aHUS. Prof Thorsten Feldkamp concluded by giving an overview of the latest clinical trial data on the efficacy and safety of eculizumab in the management of aHUS.\",\"PeriodicalId\":326555,\"journal\":{\"name\":\"EMJ Hematology\",\"volume\":\"102 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-07-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"EMJ Hematology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33590/emjhematol/10310448\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"EMJ Hematology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33590/emjhematol/10310448","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
Alexion卫星研讨会由Pier Mannuccio Mannucci教授介绍，他介绍了血栓性微血管病变(TMAs)的历史。Paul Coppo教授概述了TMAs和非典型溶血性尿毒综合征(aHUS)和血栓性血小板减少性紫癜(TTP)的鉴别诊断。他强调了适当的鉴别诊断的重要性，以便尽快开始适当的治疗，最终使患者获得更好的结果。Javier de la Rubia教授讨论了补体途径的作用以及遗传异常如何导致aHUS的失调。Thorsten Feldkamp教授总结了eculizumab在aHUS治疗中的有效性和安全性的最新临床试验数据。
The Multiple Facets of Thrombotic Microangiopathies
The Alexion satellite symposium was introduced by Prof Pier Mannuccio Mannucci who provided an introduction to the history of thrombotic microangiopathies (TMAs). Prof Paul Coppo gave an overview of TMAs and the differential diagnosis of atypical hemolytic-uraemic syndrome (aHUS) and thrombotic thrombocytopaenic purpura (TTP). He emphasised the importance of a suitable differential diagnosis in order to initiate an appropriate treatment as soon as possible, eventually allowing better patient outcomes. Prof Javier de la Rubia discussed the role of the complement pathway and how genetic abnormalities can lead to dysregulation in aHUS. Prof Thorsten Feldkamp concluded by giving an overview of the latest clinical trial data on the efficacy and safety of eculizumab in the management of aHUS.
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