Formulation and Evaluation of Novel Gum Based Drug Delivery System of An Antiemetic Drug

The study was to formulate and evaluate medicated chewing gum of meclizine hydrochloride, an antiemetic drug used in nausea, vomiting and motion sickness. The chewing gums were prepared by direct compression method using different ratio of directly compressible gum base (Pharmagum S) in order to obtain optimized formulation. Eight different formulations of chewing gums of meclizine hydrochloride were prepared, which contained various concentration of pharmagum S and Soya powder. The chewing gums which prepared by direct compression method were characterized by pre- compression characters, post compression character, buccal absorption study, drug content and in vitro drug release studies. All the formulations gave satisfactory results in terms of pre compression characters, post compression character, drug content, and in vitro drug release. The best compression characters and 97.88±0.69 % in vitro drug release profile were achieved in formulation MCG5 with a gum and soya powder concentration of 775 mg and 140 mg and FTIR study of optimized MCG5 has shown satisfactory result in terms of drug: polymer compatibility. So MCG5 was taken as optimized batch