Cellphone radiofrequency radiation induced inflammatory response and oxidative stress in rat brain

The exponential worldwide growth in the use of mobile phones has raised concerns regarding potential harmful effect of exposure to radiofrequency modulated electromagnetic field radiations. Of particular concern has been the effect on brain and hippocampus in specific. Oxidative stress has been proposed as the possible underlying mechanism responsible for radio frequency (RF) effects on nervous system. It has also been known that Stressful events affect the immune system by reducing the cellular response to mitogen stimulation, decreasing production of natural killer cell activity and altering levels of cytokines. An important and detrimental consequence of increased cytokine production is the induction of nitric oxide (NO) and reactive oxygen species. However reports on direct correlation between exposure to RF radiation and immune response has been inconsistent. Thus the present study was undertaken to determine if long term exposure to RF cause inflammatory cytokines mediated oxidative stress in brain.