{"title":"抗jo -1阳性间质性肺疾病的临床特点","authors":"Shihwan Chang, M. H. Shin, J. Shin, M. Park","doi":"10.1183/13993003.congress-2019.pa5183","DOIUrl":null,"url":null,"abstract":"Anti-Jo-1-syndrome is the most common form of antisynthetase syndrome, which often presents with interstitial lung disease (ILD) and polymyositis/dermatomyositis(PM/DM). Little is understood how the presence of PM/DM affects the clinical presentation of ILD patients with anti-Jo-1-antibody (Jo-1-ILD). We aim to characterize Jo-1-ILD by comparing patients with PM/DM (PM/DM-ILD) and without PM/DM (non-PM/DM-ILD). In this retrospective review, 49 Jo-1-ILD patients diagnosed at our institution from January 2005 to June 2018 were included. Clinical, radiologic, and histologic features of 20 PM/DM-ILD and 29 non-PM/DM-ILD patients were compared. PM/DM-ILD patients were younger at ILD diagnosis than non-PM/DM-ILD (51.0 years vs. 64.5 years, p PM/DM-ILD and non-PM/DM-ILD show similar clinical characteristics, except for age at diagnosis, anti-Ro status and medical treatment. The presence of PM/DM does not significantly affect the clinical course of Jo-1-ILD.","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"112 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical characteristics of anti-Jo-1-positive interstitial lung disease\",\"authors\":\"Shihwan Chang, M. H. Shin, J. Shin, M. Park\",\"doi\":\"10.1183/13993003.congress-2019.pa5183\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Anti-Jo-1-syndrome is the most common form of antisynthetase syndrome, which often presents with interstitial lung disease (ILD) and polymyositis/dermatomyositis(PM/DM). Little is understood how the presence of PM/DM affects the clinical presentation of ILD patients with anti-Jo-1-antibody (Jo-1-ILD). We aim to characterize Jo-1-ILD by comparing patients with PM/DM (PM/DM-ILD) and without PM/DM (non-PM/DM-ILD). In this retrospective review, 49 Jo-1-ILD patients diagnosed at our institution from January 2005 to June 2018 were included. Clinical, radiologic, and histologic features of 20 PM/DM-ILD and 29 non-PM/DM-ILD patients were compared. PM/DM-ILD patients were younger at ILD diagnosis than non-PM/DM-ILD (51.0 years vs. 64.5 years, p PM/DM-ILD and non-PM/DM-ILD show similar clinical characteristics, except for age at diagnosis, anti-Ro status and medical treatment. The presence of PM/DM does not significantly affect the clinical course of Jo-1-ILD.\",\"PeriodicalId\":178396,\"journal\":{\"name\":\"ILD/DPLD of known origin\",\"volume\":\"112 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-09-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ILD/DPLD of known origin\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1183/13993003.congress-2019.pa5183\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ILD/DPLD of known origin","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1183/13993003.congress-2019.pa5183","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Clinical characteristics of anti-Jo-1-positive interstitial lung disease
Anti-Jo-1-syndrome is the most common form of antisynthetase syndrome, which often presents with interstitial lung disease (ILD) and polymyositis/dermatomyositis(PM/DM). Little is understood how the presence of PM/DM affects the clinical presentation of ILD patients with anti-Jo-1-antibody (Jo-1-ILD). We aim to characterize Jo-1-ILD by comparing patients with PM/DM (PM/DM-ILD) and without PM/DM (non-PM/DM-ILD). In this retrospective review, 49 Jo-1-ILD patients diagnosed at our institution from January 2005 to June 2018 were included. Clinical, radiologic, and histologic features of 20 PM/DM-ILD and 29 non-PM/DM-ILD patients were compared. PM/DM-ILD patients were younger at ILD diagnosis than non-PM/DM-ILD (51.0 years vs. 64.5 years, p PM/DM-ILD and non-PM/DM-ILD show similar clinical characteristics, except for age at diagnosis, anti-Ro status and medical treatment. The presence of PM/DM does not significantly affect the clinical course of Jo-1-ILD.
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