心脏移植后免疫抑制药物和非排斥相关并发症

Dumitru Costel, D. Ghiga, S. Voidăzan, Alexandra Groșan, Dan Ş. Sîmpălean, A. Sin
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摘要

摘要背景:虽然心脏移植最初改善了心力衰竭患者的临床演变,但移植后可能会出现一些潜在的并发症,这些并发症可能与慢性免疫抑制的作用直接相关。本研究的目的是分析与免疫抑制治疗相关的移植后并发症的发生率和频率在罗马尼亚 rgu穆列斯特心血管疾病和移植研究所。材料和方法:这是一项描述性研究,包括罗马尼亚穆列斯乌姆心血管疾病和心脏移植研究所2000年至2017年间接受心脏移植的71名患者中的53名患者。数据从患者档案中收集,包括人口统计、临床和实验室数据,以及与免疫抑制治疗相关的移植后并发症的信息。结果:心脏移植患者的平均年龄为40.72±14.07岁,以男性(84.91%)居多,居住环境为城市(56.60%)。平均住院时间为33.6天。在患者总数中,有7例(13.2%)出现移植后细菌感染,而在研究人群中发现乙型肝炎、弓形虫和巨细胞病毒感染的抗体或感染史的发生率相对较高。结论:术后感染可能是最常见的移植后病理,主要原因是免疫抑制药物的使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunosuppressive Medication and Non-Rejection-Related Complications Following Heart Transplantation
Abstract Background: Although the clinical evolution of a patient with heart failure is initially improved by transplantation, a number of potential complications may occur in the post-transplant period, which may be directly related to the effects of chronic immunosuppression. The purpose of this study was to analyze the occurrence and frequency of post-transplant complications related to immunosuppressive treatment in the Institute of Cardiovascular Diseases and Transplantation of Târgu Mureș, Romania. Material and methods: This is a descriptive study including 53 patients out of a total of 71 patients who underwent cardiac transplantation between 2000 and 2017 in the Institute of Cardiovascular Disease and Cardiac Transplantation in Târgu Mureș, Romania. Data were collected from the patient files and included demographic, clinical and laboratory data, as well as information about post-transplant complications related to immunosuppressive treatment. Results: The mean age of patients undergoing heart transplantation was 40.72 ± 14.07 years, the majority of patients being male (84.91%) and living in an urban environment (56.60%). The average length of hospital stay was 33.6 days. From the total number of patients, 7 (13.2%) presented post-transplantation bacterial infections, while antibodies indicating the presence or history of B hepatitis, toxoplasma, and cytomegalovirus infection were identified with a relatively high incidence in the study population. Conclusions: Infections following surgery are probably the most common post-transplant pathology, the primary reason being the administration of immunosuppressive medication.
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