C. Pacheco-Soares, Roberta Kelly de Faria Souza, Isabel Chaves Silva Carvalho, Renata A. Canevari, B. H. Godoi, Carlos Dailton G. O. Moraes, R. Ricci, Juliana Ferreira Strixino
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The role of proteoglycan genes in PDT-resistant HEp-2 cells
Optimizing the parameters of PDT for specific cancer cells by identifying the mechanisms involved in the process represents a considerable tool for the development of photosensitizer delivery systems and the improvement of PDT targets for cancer. Proteoglycans, important constituents of extracellular matrix (ECM) play an important role in both progression and inhibition of tumor development. This study determines by gene expression whether proteoglycan are associated with PDT resistance observed in human epidermoid larynx carcinoma cells (HEp-2). We conclude that PDT increases the expression of DECORIN and BIGLYCAN genes, involved in metastatic dissemination, leading to inhibitory effect growth in Hep-2 cells
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