High capacity data hiding method in DNA with mutation handling

DNA engineering and sequencing technology have great influence to boost DNA computing world. With superior capability to record information to magnetic storage, many researches are done to achieve the maturity of DNA storage and secure communication. The new data embedding method explained in this paper is designed to insert binary data into noncoding regions of DNA sequence in order to preserve its biological function. To reach a high standard of security and capacity, data is encrypted, translated, and then encoded accordingly into DNA sectors using a reference-dependent mechanism. Error correction method using Reed-Solomon encoder and parity check gives a good error handling against substitution and insertion or deletion (indel) mutations. Simulations show that proposed method has higher bit-per-nucleotide (bpn) value even it is restricted to noncoding regions only.