个性化胰岛素治疗系统控制算法的计算机测试

2021 IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering (ElConRus) Pub Date : 2021-01-26 DOI:10.1109/ElConRus51938.2021.9396210

K. V. Pozhar, N. A. Bazaev, E. L. Litinskaia

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引用次数: 1

摘要

开发血糖控制闭环系统是糖尿病治疗的主要研究方向之一。提出了血糖维持在生理范围内的控制算法。该控制器包括用于自动调整基础胰岛素输注速率的比例调节和最佳剂量计算。该算法考虑了连续血糖测量、膳食数据和一些患者个人数据，如基础胰岛素输注率和胰岛素敏感性。采用UVA/Padova 1型糖尿病模拟器对所提出的控制器进行了硅测试，该模拟器允许进行葡萄糖代谢模拟以及葡萄糖计和胰岛素泵建模。对9名成人和10名青少年4餐24小时闭环调节的模拟结果表明，该算法有望应用于闭环血糖控制系统

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In Silico Testing of a Control Algorithm for a Personalized Insulin Therapy System

Developing of a closed-loop system for blood glucose control is one of the main research lines in the diabetes mellitus treatment. The work proposes the control algorithm for blood glucose maintenance in the physiological range. The controller includes proportional regulation for automatic adjustment of the basal insulin infusion rate and optimal bolus calculation. The algorithm takes into account continuous blood glucose measuring, meal data and some personal patient data such as basic basal insulin infusion rate and insulin sensitivity. In silico tests of the proposed controller were carried out with the UVA/Padova type 1 diabetes mellitus simulator which allows glucose metabolic simulation as well as glucose meter and insulin pump modeling. Simulations of 24-hour closed-loop regulation with 4 meals for 9 adults and 10 adolescents shows promising results for the algorithm potential appliance in a closed-loop blood glucose control system

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2021 IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering (ElConRus)

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