小檗碱抑菌及植物化学成分的筛选。水果提取物抗呼吸道病原体

S. Gautam, Sanjay Kumar Navneet
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引用次数: 1

摘要

用不同的溶剂提取小野藤果实提取物,并用琼脂孔扩散法测定其对5种呼吸道感染病原菌的抑菌性能。从该植物中,所有研究的提取物都显示出对被测微生物的抑制作用。甲醇对肺炎链球菌和铜绿假单胞菌的抑制作用在15.3±0.28 ~ 20.6±0.57 mm之间,抑菌活性最高,抑菌活性最低。采用两倍连续稀释法固定MIC,记录甲醇提取物浓度为3.1212.5 mg/ml时的MIC。植物化学研究发现次生代谢产物包括生物碱、黄酮类、糖苷、类固醇、萜烯、皂苷和单宁等。结果表明,细小芽胞杆菌具有明显的抗微生物活性,可用于呼吸道疾病的药物开发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
SCREENING OF ANTIBACTERIAL AND PHYTOCHEMICAL CONSTITUENTS OF MALVA PARVIFLORA LINN. FRUIT EXTRACTS AGAINST RESPIRATORY TRACT PATHOGENS
M. parviflora fruit extracts was subjected for extraction with different solvents and tested for antibacterial property by agar well diffusion method against five bacterial pathogens responsible for respiratory tract infections. From this plant, all the studied extracts revealed inhibitory action towards tested microorganisms. Highest inhibition was in methanol and ranged between 15.3±0.28 to 20.6±0.57 mm with uppermost activity against S. pneumoniae and lowest against P. aeruginosa respectively. The MIC were fixed by two-fold serial dilution method and recorded for methanol extracts at 3.1212.5 mg/ml. Phytochemical study revealed the variable presence of secondary metabolites including alkaloids, flavonoids, glycosides, steroids, terpenes, saponins and tannins. From the results, it can be concluded that M. parviflora has significant bioactivity against tested microorganisms and can be utilized in drug development against respiratory ailments.
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