在β-冠状病毒感染期间，VMP1和TMEM41B对DMV的形成至关重要

The Journal of Cell Biology Pub Date : 2022-05-10 DOI:10.1083/jcb.202112081

Mingming Ji, Meng Li, Long Sun, Hongyu Zhao, Ying Li, Lulu Zhou, Zhenni Yang, Xin Zhao, Wenyan Qu, Hanbing Xue, Ze Zheng, Yiming Li, H. Deng, Yan G Zhao

{"title":"在β-冠状病毒感染期间，VMP1和TMEM41B对DMV的形成至关重要","authors":"Mingming Ji, Meng Li, Long Sun, Hongyu Zhao, Ying Li, Lulu Zhou, Zhenni Yang, Xin Zhao, Wenyan Qu, Hanbing Xue, Ze Zheng, Yiming Li, H. Deng, Yan G Zhao","doi":"10.1083/jcb.202112081","DOIUrl":null,"url":null,"abstract":"Ji et al. show that the autophagy proteins VMP1 and TMEM41B are required for β-coronavirus infection, and they function at different steps during DMV biogenesis. TMEM41B is involved in nsp3/4 binding and ER zippering, while VMP1 is essential for bending the paired ER into DMVs.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"83 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"20","resultStr":"{\"title\":\"VMP1 and TMEM41B are essential for DMV formation during β-coronavirus infection\",\"authors\":\"Mingming Ji, Meng Li, Long Sun, Hongyu Zhao, Ying Li, Lulu Zhou, Zhenni Yang, Xin Zhao, Wenyan Qu, Hanbing Xue, Ze Zheng, Yiming Li, H. Deng, Yan G Zhao\",\"doi\":\"10.1083/jcb.202112081\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Ji et al. show that the autophagy proteins VMP1 and TMEM41B are required for β-coronavirus infection, and they function at different steps during DMV biogenesis. TMEM41B is involved in nsp3/4 binding and ER zippering, while VMP1 is essential for bending the paired ER into DMVs.\",\"PeriodicalId\":343306,\"journal\":{\"name\":\"The Journal of Cell Biology\",\"volume\":\"83 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-05-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"20\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Cell Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1083/jcb.202112081\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Cell Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1083/jcb.202112081","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 20

摘要

Ji等人的研究表明，β-冠状病毒感染需要自噬蛋白VMP1和TMEM41B，它们在DMV生物发生过程中发挥不同的作用。TMEM41B参与nsp3/4结合和内质网压缩，而VMP1对于将配对的内质网弯曲成dmv至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

VMP1 and TMEM41B are essential for DMV formation during β-coronavirus infection

Ji et al. show that the autophagy proteins VMP1 and TMEM41B are required for β-coronavirus infection, and they function at different steps during DMV biogenesis. TMEM41B is involved in nsp3/4 binding and ER zippering, while VMP1 is essential for bending the paired ER into DMVs.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

The Journal of Cell Biology

自引率

0.00%

发文量