V Kofránek, O Parízek, V Svoboda, D Bubeníková, J Machek
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引用次数: 1
摘要
以19.7和55.9 μ ci /kg体重的226Ra单次注射后，测定年轻雌性小鼠成骨细胞3H-TDR标记指数及腰椎和股骨远端骨骺内腔剂量的时间过程。对注射核素后2小时至28天死亡的动物的选定骨区进行检查。确定了相对标记指数的变化取决于α辐射的吸收剂量。讨论了这些实验结果与骨肉瘤诱导和定位的可能相关性。
3H-TDR labelling of osteoprogenitor cells after 226RA incorporation in mice.
The time course of 3H-TDR labelling index of osteoprogenitor cells and the doses in endosteum of lumbar vertebra and distal femoral epiphysis were autoradiographically determined in young female mice after single injections of 19.7 and 55.9 micronCi/kg body weight of 226Ra. The selected bone areas were examined in animals killed 2 hours to 28 days after the injection of nuclide. It was ascertained that changes in the relative labelling index are depending on the absorbed doses of alpha radiation. The possible relevance of these experimental findings for the explanation of the osteosarcoma induction and localization is discussed.
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