A model-experiment loop to optimise data requirements for ecotoxicological risk assessment with mesocosms

Recommendation In Ecotoxicology, the toxicity of chemicals is usually quantified for individuals under laboratory conditions, while in reality individuals interact with other individuals in populations and communities, and are exposed to conditions that vary in space and time. Microand mesocosm experiments are therefore used to increase the ecological realism of toxicological risk assessments. Such experiments are, however, labour-intensive, costly, and cannot, due to logistical reasons, implement all possible factors or interests (Henry et al. 2017). Moreover, as such experiments often include animals, the number of experiments performed has to be minimized to reduce animal testing as much as possible.