Pirshing T. Kurtas, Rafah H. Al-Maroof, Kawa F Dizaye
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The Effects of Salbutamol , Methylprednisolone and their Combination on the Histology of Trachea in Rabbits
Goblet cell hyperplasia is a prominent feature in animals with atopic asthma and salbutamol enhances goblet cell hyperplasia and airway hyperresponsiveness in rats receiving salbutamol (3). Tamaoki et al. in 2004 stated that the b2adrenoceptor receptor agonist stimulates proliferation of airway epithelial cells and produces airway wall thickening in vivo via mitogen activated protein (MAP) kinase-dependent pathway, and these effects are prevented by inhaled corticosteroids (4).
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