甘聚糖及其在抗击COVID-19中的作用

S. Chatterjee, Snigdha Saha
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引用次数: 1

摘要

新发现的乙型冠状病毒,即2019年的新型冠状病毒,与一种名为COVID-19的传染性呼吸道疾病有关。这种疾病已被世界卫生组织(卫生组织)宣布为“大流行”。冠状病毒进入人呼吸道上皮细胞取决于宿主细胞受体ACE2与病毒s -糖蛋白的相互作用。然而,细胞表面受体和包膜糖蛋白之间的这种类型的分子识别是由特定的聚糖表位介导的,并归因于病毒通过膜融合进入。聚糖是所有生物体所必需的生物分子,具有服务于结构、能量储存和系统调节的作用。聚糖屏蔽在隐藏表面S蛋白不被分子识别方面起着至关重要的作用。聚糖结合蛋白(GBPs)的免疫调节特性,如凝集素,使其成为有吸引力的疫苗佐剂候选物。涉及COVID-19和疾病中凝集素途径激活补体系统的研究需要时间。涉及补体系统的先天免疫反应可能对一系列微生物感染产生不同的生物学效应。糖蛋白类方法的进展,特别是某些凝集素的免疫调节作用,对于提高COVID-19和其他大流行的治疗效果是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Glycan and Its Role in Combating COVID-19
Newly identified beta-coronavirus i.e. the 2019 novel coronavirus is associated with a contagious transmittable respiratory disease called COVID-19. This disease has been declared as a “pandemic” by the World Health Organization (WHO). The entry of coronavirus in the human respiratory epithelial cells depends upon the interaction between host cell receptor ACE2 and viral S-glycoprotein. However, this type of molecular recognition in between cell surface receptors and envelope glycoproteins are mediated by specific glycan epitopes and attribute to viral entry through membrane fusion. Glycans are essential biomolecules made by all living organisms, have roles in serving structure, energy storage, and system regulatory purposes. The glycan shield plays a crucial role in concealing the surface S protein from molecular recognition. The immunomodulatory properties of Glycan-binding proteins (GBPs) like Lectins, build them as an attractive candidates for vaccine adjuvant. Investigations involving the complement system activation by the lectin pathway in COVID-19 and diseases are in need of the hour. The innate immune response involving complement system could have varied biological effects against an array of microbial infections. The advances in glycoprotein style methods especially immunomodulatory action of some lectins are necessary to boost the effectiveness of treatment of COVID-19 and other pandemics.
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