Catalytic Cerium Oxide Nanoparticles in Nanomedicine and Their Use in Liver Diseases

In this work, we aim to provide a better understanding on how to analyze the results obtained using Cerium Oxide (CeO2) nanoparticles for medical applications while showing some results for the case of liver disease. Thus, the manuscript is divided in two main sections. First, we discuss the bibliography of the safety aspects of the use of Cerium Oxide for medicine, since we have seen discrepancies between reports on its proven anti-inflammatory activity together with other reporting toxicity. The evolution of the nanoparticles inside the body make several parameters, such as aggregation state or surface evolutions, as critical determinants that need to be carefully addressed to better understand their potential clinical benefits. Second, we show the usefulness of enhancing the stability of CeO2 nanoparticles in the physiological media for the treatment of liver diseases. Liver is the organ where nanoparticles passively accumulate and thus, a logical place to start the studies of the in vivo evolution and activity of this material.