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Jurnal Wiyata: Penelitian Sains dan Kesehatan Pub Date : 2022-12-31 DOI:10.56710/wiyata.v9i2.615

Paulina Maya Octasari, Daniar Kusuma Wardani, Elisabeth Lionida Sari

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摘要

背景:类黄酮是一种具有镇痛和抗炎作用的化合物。木薯叶含有黄酮类化合物，主要成分为芦丁。木薯叶乙醇提取物的常规类黄酮含量为4.987%，具有开发中药的潜力。目的:研究木薯叶乙醇提取物(eds)的镇痛和抗炎作用，以及不同剂量的提取物对其镇痛和抗炎作用的影响。方法:以2 ~ 3月龄、体重20 ~ 30克的小鼠为研究对象，采用完全随机、单向模式的实验研究。镇痛试验采用1%乙酸诱导的拉伸法，抗炎试验采用1%角叉菜胶诱导的水肿厚度测量法。对保护百分率、保护百分率的变化、抗炎能力百分率的结果进行统计分析。结果:所制得的黄酮类化合物呈阳性，色绿黑色，味苦，干燥损失7%，w/w产率12.31%。剂量为70时，eds具有镇痛作用;140;280 (mg/kgBB)，保护率26.59%;24.45%;和21.96%;保护百分比变化65.75%;68.51%;和71.72%。剂量为35;70;140 (mg/kgBW)的抗炎能力百分比为44.93%;37.34%;和30.75%。结论:愈大剂量，愈强的镇痛作用愈强，愈弱的抗炎作用愈强

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UJI DAYA ANALGETIK DAN ANTIINFLAMASI EKSTRAK ETANOLIK DAUN SINGKONG (Manihot utilissima Pohl.) PADA MENCIT GALUR SWISS

Background: Flavonoids are compounds that can function as analgesics and anti-inflammatory. Cassava leaves are known to contain flavonoids with the main content of rutin. The routine flavonoid content in the ethanolic extract of cassava leaves is 4.987% so that it has the potential to be developed as traditional medicine. Objective: This study aimed to determine the analgesic and anti-inflammatory properties of cassava leaf ethanolic extract (EEDS) and the effect of varying doses of EEDS on analgesic and anti-inflammatory properties. Methods: This study was a completely randomized experimental study with a unidirectional pattern in mice aged 2-3 months and weighing 20-30 grams. Analgesic testing method used the stretching method with 1% acetic acid as the induction, while the anti-inflammatory test used the edema thickness measurement method with 1% carrageenin induction. The results of the percentage of protection, the change in the percentage of protection, and the percentage of anti-inflammatory power were statistically analyzed. Results: The results showed that EEDS was green-black in color, bitter in taste, 7% drying loss, 12.31% w/w yield and positive for flavonoids. EEDS has analgesic power at a dose of 70; 140; and 280 (mg/kgBB) with a percentage of protection of 26.59%; 24.45%; and 21.96%; change in percentage of protection by 65.75%; 68.51%; and 71.72%. EEDS at a dose of 35; 70; and 140 (mg/kgBW) has a percentage of anti-inflammatory power of 44.93%; 37.34%; and 30.75%. Conclusion: The higher the dose of EEDS, the higher the analgesic power but the lower the anti-inflammatory power

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Jurnal Wiyata: Penelitian Sains dan Kesehatan

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