Feasibility Controlling Hemoglobin A1c by Oral Hygiene Improvement: A Pilot Study

Purpose: Patients with diabetes mellitus are prone to be bacteremia. The major side effect of diabetes mellitus is caused by bacteremia. However, conventional periodontal treatment does not focus mainly on the elimination of pathogenic bacteria. Therefore, the aim of this study was to the management of oral bacteria improve some symptoms of diabetes mellitus. Material and Method: We monitored Hemoglobin A1c (HbA1c) of five subjects after removed oral bacteria on the tooth surface by antibiotics using custom made tray. By using the results, simulation model was constructed. Result: By the simulation, HbA1c levels declined over time and decreased to 6.0%. However, it took at least 600 days to come up to 6.0%. The higher the level of HbA1c at baseline, the more time takes to improve HbA1c level. Subjects with 7.3% HbA1c at baseline required 2,400 days to achieve 6.0% HbA1c. Conclusion: The results of this study suggest that HbA1c may be improved by oral bacterial control. Clinical studies suggest that a long observational period is required to obtain high quality evidence.? Keywords: Oral hygiene; Hemoglobin A1c; Mixed effect model