精确DNA碱基召唤的聚类方法

Conference Record of the Thirty-Sixth Asilomar Conference on Signals, Systems and Computers, 2002. Pub Date : 2002-11-03 DOI:10.1109/ACSSC.2002.1197197

E. Manolakos

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引用次数: 0

摘要

通过使用智能碱基调用算法，将DNA色谱的有效读取长度常规地扩展到1kps以上，这对基因组学研究非常有用，因为在许多情况下，一个基因的整个编码区域可以适合一个长读取。通过将色谱图分割成碱基调用“事件”，根据它们所代表的碱基数量进行标记，将碱基调用作为模式分类问题进行了公式化。概述了可用于解决该问题的两种无监督聚类方法。

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Clustering methods for accurate DNA base-calling

Routinely extending the useful read-lengths of DNA chromatograms beyond 1 kps by employing intelligent base-calling algorithms will be extremely useful to genomics research because in many cases the entire coding region of a gene could fit into a single long read. By segmenting the chromatograms into base-call "events" to be labeled in terms of the number of bases they represent, base-calling as a pattern classification problem is formulated. An overview of two unsupervised clustering methods that could be used for its solution is presented.

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Conference Record of the Thirty-Sixth Asilomar Conference on Signals, Systems and Computers, 2002.

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