前测-后测研究在前测分数筛选下的非正态性评估

Y. Kawata, Manabu Iwasaki
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引用次数: 0

摘要

各种研究领域经常采用前测后测研究设计,以消除个体差异,从而精确评估治疗效果。在前测后测设计中,通常对基线值进行筛选,以确定受试者是否被纳入研究。为了评估所考虑的治疗的有效性,通常采用t检验或方差分析。这种程序要求底层分布具有正态性。即使前测和后测分数共同遵循双变量正态分布,前测分数的筛选也将毫无疑问地偏离正态假设。然而,很少有研究对这种情况下的异常程度进行评估。本文检验了由预试分数筛选引起的非正态性的程度。在测试前和测试后分数的二元正态分布下,根据几种筛选方案的分布的Kullback-Leibler散度、偏度和峰度来评估偏离正态的程度。将确定最大程度偏离正常的情况。结果表明,即使在最大偏离正态性的情况下,偏离的程度也不是那么大,因此我们使用t检验和方差分析可以从稳健性的角度进行验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ASSESSMENT OF NON-NORMALITY IN PRETEST-POSTTEST RESEARCH UNDER SCREENING OF THE PRETEST SCORE
Pretest-posttest research designs are frequently employed in various research fields to eliminate individual variability so as to precisely assess treatment effects . In pretestposttest designs, screening is often performed on the baseline values to determine whether subjects are to be enrolled to the study. To assess the effectiveness of the treatment considered, the t test or the analysis of variance is often employed. Such procedures require normality of the underlying distribution. Even if the pretest and posttest scores jointly follow a bivariate normal distribution, screening of the pretest score will unquestionably depart from the normality assumption. Little research, however, has been done to assess the extent of non-normality under such a situation. The present paper examines the extent of non-normality caused by screening of the pretest scores. Under a bivariate normal distribution for pretest and posttest scores, the degree of departure from normality is assessed in terms of Kullback-Leibler divergence, skewness, and kurtosis of distributions for several types of screening schemes. Situations of maximum departure from normality will be identified. It is shown that, even at such a maximum departure from normality, the extent of departure is not so large, and hence our use of the t test and the analysis of variance can be validated from the viewpoint of robustness.
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