{"title":"维生素E对NO2诱导的人红细胞氧化还原变化的影响。","authors":"S M Cassan, D H Simmons","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Human erythrocytes admixed with vitamin E supplements (50 mug/ml) were exposed to NO2 in concentrations of 200-600 p.p.m. at 37 degrees C for 2 h. No protective effect against the increase in the redox ratio [NAD+]/[NADH]normally produced by NO2 was observed. It is postulated that NO2 increases the redox ratio by a mechanism independent of that producing hemolysis and prevented by vitamin E. This may involve alteration of NADH dependent enzymes by NO2.</p>","PeriodicalId":75826,"journal":{"name":"Environmental physiology & biochemistry","volume":"5 3","pages":"201-7"},"PeriodicalIF":0.0000,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effect of vitamin E on NO2 induced redox changes in the human erythrocyte.\",\"authors\":\"S M Cassan, D H Simmons\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Human erythrocytes admixed with vitamin E supplements (50 mug/ml) were exposed to NO2 in concentrations of 200-600 p.p.m. at 37 degrees C for 2 h. No protective effect against the increase in the redox ratio [NAD+]/[NADH]normally produced by NO2 was observed. It is postulated that NO2 increases the redox ratio by a mechanism independent of that producing hemolysis and prevented by vitamin E. This may involve alteration of NADH dependent enzymes by NO2.</p>\",\"PeriodicalId\":75826,\"journal\":{\"name\":\"Environmental physiology & biochemistry\",\"volume\":\"5 3\",\"pages\":\"201-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1975-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Environmental physiology & biochemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental physiology & biochemistry","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The effect of vitamin E on NO2 induced redox changes in the human erythrocyte.
Human erythrocytes admixed with vitamin E supplements (50 mug/ml) were exposed to NO2 in concentrations of 200-600 p.p.m. at 37 degrees C for 2 h. No protective effect against the increase in the redox ratio [NAD+]/[NADH]normally produced by NO2 was observed. It is postulated that NO2 increases the redox ratio by a mechanism independent of that producing hemolysis and prevented by vitamin E. This may involve alteration of NADH dependent enzymes by NO2.
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