Sensitivity Analysis and Parameter Identification of a Cardiovascular Model in Aortic Stenosis

The objective of this study is to propose a model-based method, adapted to patients with severe aortic stenosis (AS), in order to reproduce left ventricle (LV) pressure and volume from patient specific data. A formal sensitivity analysis is proposed, focused on left ventricle volume and pressure. The most influent parameters of this analysis are then selected to be identified in a parameter identification strategy and provide a patient specific pressure curve. This was implemented on 3 AS patients and a close match was observed between experimental and simulated pressure and volume curves. The global root mean square error (RMSE) for pressure and volume curves are respectively 21.8 $(\pm 1.8)$ mmHg and 14.8 $(\pm 9.4)ml$,. The model-based approach proposed shows promising results to generate accurate LV pressure and volume in AS case.