电流导向多极多点深部脑刺激器的输出阶段

V. Valente, A. Demosthenous, R. Bayford
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引用次数: 11

摘要

临床深部脑刺激(DBS)是基于使用圆柱形电极驱动单极或双极配置。模拟场在电极周围对称扩散,调制目标和非目标神经结构。最近的进展主要集中在基于高密度分段电极的新型刺激技术上,这种技术可以实现电流控制和场整形能力。本文介绍了一种多通道电流转向刺激器输出级的结构,该级允许单极、双极、三极和四极多位点刺激。输出级的核心包括N个独立的高遵从性电流驱动器(hccd),能够在10个不同的电流范围内提供高达1.5 mA的互补电流。由于由5-32解码器控制的2-32多路复用器,每个N hccd可以驱动多达8个相邻的电极触点。HCCD采用HV 0.18μm CMOS工艺设计。在Cadence Spectre中对电路进行了仿真,并给出了仿真结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Output stage of a current-steering multipolar and multisite deep brain stimulator
Clinical deep brain stimulation (DBS) is based on the use of cylindrical electrodes driven in monopolar or bipolar configurations. The simulation field spreads symmetrically around the electrode modulating both targeted and non-targeted neural structures. Recent advances have focused on novel stimulation techniques based on the use of high-density segmented electrodes, which allow current-steering and field-shaping capability. This paper presents the architecture of a multi-channel current-steering stimulator output stage that allows for monopolar, bipolar, tripolar and quadripolar multi-site stimulation. The core of the output stage comprises N independent high-compliance current drivers (HCCDs), capable of delivering up to 1.5 mA complementary currents in 10 different current ranges. Each of the N HCCDs can drive up to 8 adjacent electrode contacts thanks to a 2-32 multiplexer controlled by a 5-32 decoder. The HCCD was designed in a HV 0.18μm CMOS process. The circuits were simulated in Cadence Spectre and simulated results are presented in the paper.
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