Oxidative Polymerization of Dopamine: A High-Definition Multifunctional Coatings for Electrospun Nanofibers - An Overview

The invention that catecholamines undergo oxidative polymerization under alkaline con- ditions and form adhesive nanocoatings on wide variety of substrates has ushered their potential utility in engineering and biomedical applications. The oxidative polymeriza- tion of catecholamines can be triggered by light, chemical and physical methods, thus representing one of the widely explored surface coating methods. The overall objectives of this chapter are to compile the various methods of accomplishing surface coatings and compare the structural diversity of catecholamines. The progress achieved so far on polydopamine (pDA) coatings on electrospun polymers will be discussed. Finally, we will summarize the research efforts on catecholamine coatings for biomedical applica - tions as well as their potential as a high definition coating method. vein endothelial cells on pDA- or gelatin-coated PCL nanofiber mats. The results showed that pDA-coated PCL mats displayed threefold to sevenfold higher cell viability, cell attachment and spreading with well-stretched cytoskeletal components than gelatin-coated PCL nanofi -bers. In the cells grown on pDA-coated mats displayed increased expression of endo thelial cell markers highlighting the healthy status of the cells. to the pDA of poly(L-lactic acid) (PLLA) higher mouse adipose-derived cell (mASC) adhesion, penetration and compared PCL/gelatin nanofiber layer-by-layer of key osteogenic marker proteins calcium utility of electrospun hard tissue performed pDA coating on glutaraldehyde crosslinked electrospun polymers. The pDA-coated PVA was shown to have excellent shape recovery properties and higher cell adhesion, spreading, penetration and PVA scaffolds. nanofibers enhanced mouse myoblast adhesion, increased expression of myosin