在皮质发生过程中，NCAM通过profilin2调节神经祖细胞的时间特异性

The Journal of Cell Biology Pub Date : 2019-12-09 DOI:10.1083/jcb.201902164

Rui Huang, De-Juan Yuan, Shao Li, Xue-Song Liang, Yue Gao, Xiaoyan Lan, Hua-min Qin, Yu-Fang Ma, Guang-Yin Xu, M. Schachner, V. Sytnyk, J. Boltze, Quan-Hong Ma, Shen Li

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引用次数: 12

摘要

NCAM在皮质发生中的作用尚不完全清楚。作者证明NCAM通过依赖于profin2的肌动蛋白聚合调控NPC的增殖和命运决定。这一发现揭示了NCAM在神经发育和精神障碍中的功能。

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NCAM regulates temporal specification of neural progenitor cells via profilin2 during corticogenesis

The role of NCAM in corticogenesis is incompletely understood. The authors demonstrate that NCAM controls NPC proliferation and fate decision through profilin2-dependent regulation of actin polymerization. This finding sheds new light on NCAM’s functions in neurodevelopmental and mental disorders.

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来源期刊

The Journal of Cell Biology

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