基于氧化石墨烯的微rna -10b荧光传感纳米平台的研制

2021 IEEE International Conference on Design & Test of Integrated Micro & Nano-Systems (DTS) Pub Date : 2021-06-07 DOI:10.1109/DTS52014.2021.9497926

Maroua Moslah, K. Djebbi, C. Tlili, C. Dridi, Deqiang Wang

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引用次数: 0

摘要

在此，我们开发了一种用于简单检测miRNA-10b的荧光传感器，该传感器结合了氧化石墨烯(GO)的荧光猝灭能力和双特异性核酸酶(DSN)介导的靶循环扩增。我们的传感器对miRNA-10b具有理想的灵敏度，在75分钟内可达到530 fM的检测限。此外，我们的传感器对区分靶miRNA和其他microrna具有良好的选择性。

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Development of graphene oxide-based fluorescent sensing nanoplatform for microRNA-10b detection

Herein, we develop a fluorescent sensor for simple detection of miRNA-10b, which combines the fluorescence quenching ability of graphene oxide (GO) and the duplex-specific nuclease (DSN) mediated target recycling amplification. Our sensor exhibits desirable sensitivity for miRNA-10b with a 530 fM detection limit that could be achieved within 75 min. Furthermore, our sensor showed good selectivity for discriminating target miRNA and other microRNAs.

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2021 IEEE International Conference on Design & Test of Integrated Micro & Nano-Systems (DTS)

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