A. Eiler, Pierre-Marie Faure, J. Sugita, S. Ihida, D. Zhu, Y. Sakai, K. Fujiu, K. Komori, H. Toshiyoshi, A. Tixier-Mita
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Thin-Film Transistor Platform for Electrophysiological and Electrochemical Characterization of Biological Cells
This paper presents a locally-addressable 2-dimensional arrayed transparent electrode platform with integrated Thin-Film Transistor (TFT) for electrophysiology. 2D electrical measurements on 28 parallel-connected lines selected from a 22,500 microelectrode array were successfully performed for heart cell investigation for the first time. Amperometry measurement was also demonstrated using transparent electrodes functionalized with Ag/AgCl by additive manufacturing. The applicability of this transparent TFT substrate platform to electrochemical sensors was confirmed by experiments. The platform offers a unique access to versatile lab-on-a-chip devices that integrate many measurement techniques on one chip (electrical, chemical and optical) for the study of large cell cultures, tissues or organoids.
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