2564: Total human eye allotransplantation (THEA): Protocol optimization of imaging modalities in a non-human primate model

2564: Total human eye allotransplantation (THEA): Protocol optimization of imaging modalities in a non-human primate model Edward H. Davidson, MA, (Cantab), MBBS, Jonathan Carney, Brian Lopresti, Maxine Reedy Miller, MD, and Kia M. Washington University of Pittsburgh, Pittsburgh, PA, USA Background To pioneer vascularized composite allotransplantation (VCA) of the human eye as a clinical reality, our group has developed the first orthotopic model for eye transplantation in the rat for testing of immunomodulation and neuroregeneration therapies. We have also performed human cadaveric studies to design surgical protocols for donor and recipient procedures ahead of advancing to a non-human primate surgical model of eye transplantation Non-invasive methodologies of graft monitoring are paramount to development of this model as well as for clinical practice in future transplantation programs.