基于计算机的子宫颈抹片细胞自动分割

Anupama Bhan, Divyam Sharma, Sourav Mishra
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引用次数: 5

摘要

宫颈癌是全世界妇女因癌症死亡的第四大原因。子宫颈抹片检查是常用的子宫颈癌筛查方法。但巴氏涂片病理检查是非常耗时的过程。因此,本文提出了一种宫颈细胞核的自动检测方法,该方法主要关注时间消耗这一自动分割的重要参数。采用双阈值边缘图对边缘进行去噪预处理,然后采用梯度力模型和气球力模型对宫颈癌细胞核进行分割。使用两个参数可变形模型来检查迭代次数和精度之间的权衡。此外,计算几何特征,如周长、面积、偏心率、平均强度等,然后使用这两种方法进行分割,以检测细胞是癌变还是正常。将计算得到的特征与每种方法进行对比。实验结果表明,使用梯度力模型进行分割的迭代次数减少,分割精度达到0.92,对临床判读具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Computer Based Automatic Segmentation of Pap smear Cells for Cervical Cancer Detection
Cervical Cancer is the fourth leading cause of death due to cancer among women worldwide. Pap Smear Test is the commonly used method for Cervical Cancer screening. But Pap Smear pathology screening is very time consuming process. Therefore, an automatic detection method of nucleus of cervical cell is proposed in this paper which mainly focuses on time consumption which is an important parameter when it comes the automatic segmentation. The pre-processing is achieved using edge map with double threshold for de-noising of edges, and then segmentation of the nucleus of cervical cancer cell is achieved using Gradient Force Model and Balloon force Model. The two parametric deformable models are used to check the trade-off between the number of iterations and accuracy. Further, geometrical features like perimeter, area, eccentricity, mean intensity etc. are calculated followed by segmentation using both methods to detect whether cell is cancerous or normal. The calculated features are contrasted with each method. The experimental results shows time consumption is reduced using gradient force model in terms of number of iterations used for segmentation with the accuracy of 0.92 which is significant for clinical interpretation.
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