基于人工神经网络mRMR特征选择的乳腺癌患者生存预测模型

W. Xing, Kangping Wang, Hui Sun, Yan Wang
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引用次数: 0

摘要

乳腺癌是世界上最常见的女性癌症之一,对女性健康构成巨大威胁。预测乳腺癌患者的生存状况对患者具有重要意义。目前,由于传统机器学习算法的分类能力较低,不足以辅助临床诊断。本研究将具有更强大分类性能的深度学习与医学诊断相结合,以提高诊断的准确性。本研究构建了最小冗余和最大相关算法(mRMR)与人工神经网络相结合的模型(MA),该模型不仅可以预测乳腺癌患者是否能存活5年以上,还可以选择使分类结果最优的特征(基因)集。在准确率方面,MA模型的分类有效性可以达到72.38%。通过对最优基因集的生存分析,获得了11个与肿瘤生存高度相关的基因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Breast Cancer Patients’ Survival Prediction Model Using mRMR Feature Selection with Artificial Neural Network
Breast cancer is one of the most common cancers among women in the world, and it poses a huge threat to women's health. Predicting the survival status of breast cancer patients is of great significance to the patients. At present, due to the low classification ability of traditional machine learning algorithms, it is not enough to assist clinical diagnosis. This study combined deep learning with more powerful classification performance with medical diagnosis to improve the accuracy of diagnosis. This study constructed a model (MA) combining min-redundancy and max-relevance algorithm(mRMR) and artificial neural network, which could not only predict whether breast cancer patients would survive for more than 5 years, but also selected the features (genes)set that made classification results optimal. In terms of accuracy, the MA model's classification effectiveness could achieve 72.38%. Through survival analysis to the optimal genes set, 11 genes highly correlated with cancer survival were obtained.
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