介孔二氧化硅纳米颗粒穿透肿瘤微组织的可行性研究

2018 Medical Technologies National Congress (TIPTEKNO) Pub Date : 2018-11-01 DOI:10.1109/TIPTEKNO.2018.8597106

Z. Yaralı, A. Uzun, D. Karaman, O. Karaman

{"title":"介孔二氧化硅纳米颗粒穿透肿瘤微组织的可行性研究","authors":"Z. Yaralı, A. Uzun, D. Karaman, O. Karaman","doi":"10.1109/TIPTEKNO.2018.8597106","DOIUrl":null,"url":null,"abstract":"Microtissues are 3D structures created to stimulate the real environment of the cell line (i.e.MCF-7). In this study, mesoporous silica with different surface modifications nanopartciles (MSN, MSN-PEI and MSN-PEI-SUCC) were added to breast cell line-generated microtissue. Thereafter, the penetration of MSNs in microtissue and the effect on the morphological tissue was investigated, and MSN-surface functinalization and increasing concentration dependent effects were observed.","PeriodicalId":127364,"journal":{"name":"2018 Medical Technologies National Congress (TIPTEKNO)","volume":"78 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Feasibility Study of Mesoporous Silica Nanoparticles Permeability through the Cancer Microtissues\",\"authors\":\"Z. Yaralı, A. Uzun, D. Karaman, O. Karaman\",\"doi\":\"10.1109/TIPTEKNO.2018.8597106\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Microtissues are 3D structures created to stimulate the real environment of the cell line (i.e.MCF-7). In this study, mesoporous silica with different surface modifications nanopartciles (MSN, MSN-PEI and MSN-PEI-SUCC) were added to breast cell line-generated microtissue. Thereafter, the penetration of MSNs in microtissue and the effect on the morphological tissue was investigated, and MSN-surface functinalization and increasing concentration dependent effects were observed.\",\"PeriodicalId\":127364,\"journal\":{\"name\":\"2018 Medical Technologies National Congress (TIPTEKNO)\",\"volume\":\"78 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2018 Medical Technologies National Congress (TIPTEKNO)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/TIPTEKNO.2018.8597106\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2018 Medical Technologies National Congress (TIPTEKNO)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/TIPTEKNO.2018.8597106","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 1

摘要

微组织是为了刺激细胞系(如mcf -7)的真实环境而创建的3D结构。本研究将具有不同表面修饰纳米颗粒(MSN、MSN- pei和MSN- pei - succ)的介孔二氧化硅添加到乳腺细胞系生成的微组织中。随后，研究了微组织中msn的渗透和对形态组织的影响，观察了msn表面功能化和浓度依赖性增强的效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Feasibility Study of Mesoporous Silica Nanoparticles Permeability through the Cancer Microtissues

Microtissues are 3D structures created to stimulate the real environment of the cell line (i.e.MCF-7). In this study, mesoporous silica with different surface modifications nanopartciles (MSN, MSN-PEI and MSN-PEI-SUCC) were added to breast cell line-generated microtissue. Thereafter, the penetration of MSNs in microtissue and the effect on the morphological tissue was investigated, and MSN-surface functinalization and increasing concentration dependent effects were observed.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

2018 Medical Technologies National Congress (TIPTEKNO)

自引率

0.00%

发文量