Tzu-Jing Yang, Tian-Neng Li, Rih-Sheng Huang, Maxwell Pan, Shu-Yu Lin, Steven Lin, Kuen-Phon Wu, L. Wang, S. Hsu
{"title":"肿瘤抑制因子BAP1的核输入受转运蛋白-1控制","authors":"Tzu-Jing Yang, Tian-Neng Li, Rih-Sheng Huang, Maxwell Pan, Shu-Yu Lin, Steven Lin, Kuen-Phon Wu, L. Wang, S. Hsu","doi":"10.1083/jcb.202201094","DOIUrl":null,"url":null,"abstract":"Yang et al. unravel the molecular mechanism by which the tumor suppressor BAP1 is shuttled into the nucleus by TNPO1. TNPO1 sterically competes with UBE2O for monoubiquitination sites within the nuclear localization sequence of BAP1 to prevent its cytoplasmic retention.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"7 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Tumor suppressor BAP1 nuclear import is governed by transportin-1\",\"authors\":\"Tzu-Jing Yang, Tian-Neng Li, Rih-Sheng Huang, Maxwell Pan, Shu-Yu Lin, Steven Lin, Kuen-Phon Wu, L. Wang, S. Hsu\",\"doi\":\"10.1083/jcb.202201094\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Yang et al. unravel the molecular mechanism by which the tumor suppressor BAP1 is shuttled into the nucleus by TNPO1. TNPO1 sterically competes with UBE2O for monoubiquitination sites within the nuclear localization sequence of BAP1 to prevent its cytoplasmic retention.\",\"PeriodicalId\":343306,\"journal\":{\"name\":\"The Journal of Cell Biology\",\"volume\":\"7 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-04-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Cell Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1083/jcb.202201094\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Cell Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1083/jcb.202201094","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Tumor suppressor BAP1 nuclear import is governed by transportin-1
Yang et al. unravel the molecular mechanism by which the tumor suppressor BAP1 is shuttled into the nucleus by TNPO1. TNPO1 sterically competes with UBE2O for monoubiquitination sites within the nuclear localization sequence of BAP1 to prevent its cytoplasmic retention.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
