[实验性高皮质大鼠在核糖核酸钠作用下的组织代谢及蛋白质含量]。

Ukrains'kyi biokhimichnyi zhurnal Pub Date : 1977-09-01
J L Germanjuk, D S Sydorenko
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引用次数: 0

摘要

多次注射acth -磷酸锌诱导的实验性高皮质可抑制1- 14c -丙氨酸和3h -蛋氨酸进入肝脏、脾脏、股方肌、血液和核浆、肝脏线粒体、小体和细胞质中蛋白质的掺入,并降低其蛋白质含量。在acth -磷酸锌联合肠内给药核糖核酸钠的作用下,所标记的氨基酸与蛋白质的结合以及所研究组织的蛋白质含量偏离正常水平的情况比仅在激素作用下的情况要小。提出了一种意见,即在临床条件下,肠内注射核糖核酸钠可能比肠外给药更可取。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Metabolism and content of proteins in rat tissues under the effect of sodium ribonucleate in experimental hypercorticism].

Experimental hypercorticism induced by multiple injections of ACTH-zinc-phosphate inhibits the incorporation of 1-14C-alanine and 3H-methionine into proteins of the liver, spleen, musculus quadratus femoris, blood and nuclear plasma, mitochondria, microsomas and cytosol of the liver as well as decreases the protein content in them. Under the effect of ACTH-zinc-phosphate in combination with enteral administration of sodium ribonucleate, the deviations from the normal level in the incorporation of the labelled amino acids into proteins and in the protein content of the tissues under study are less pronounced than under the effect of the hormone only. An opinion is advanced that enteral injection of sodium ribonucleate may be more preferable than parenteral administration of this preparation with hypercorticism under clinical conditions.

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