Antiviral activity of interferons.

INTRODUCTION.............................................................. 543 ESTABLISHMENT OF THE ANTIVIRAL STATE ........... .................... 544 Interferon Binding ................... ............................. 544 Development of Antiviral Activity................................. 546 LOCUS OF THE INTERFERON-INDUCED INHIBITION OF VIRUS GROWTH. . 547 Evidence that Interferon Treatment Inhibits Virus Uncoating ....... ........... 547 Evidence that Interferon Treatment Inhibits Transcription of the Viral Genome. 547 Evidence that Interferon Treatment Inhibits Viral Protein Synthesis ..... ...... 550 Observations in virus-infected cells ........................... 551 Observations in cell-free systems ....... .................... 552 Evidence that Interferon Treatment Inhibits Terminal Events in the Replication Cycle of Murine Leukemia Viruses ........ ................. 557 INTERFERON TREATMENT IS INEFFECTIVE IN SYSTEMS IN WHICH THE SV40 GENOME IS INTEGRATED INTO AN INTERFERON-RESISTANT VIRUS OR A HOST GENOME ........................... 559 DISCUSSION ............................. 560 LITERATURE CITED........................... 562