Effect of noradrenaline infusion in central venous catheter versus external jugular vein on the outcome of septic shock patients

Introduction Sepsis is a medical life-threatening emergency that involves dysfunction of an organ induced by the host’s dysregulated extreme response toward an infection. Sepsis is prominent worldwide causing septic mortality and numerous critical illnesses. Septic shock is defined as severe persisting hypotension that is induced by sepsis although there is an adequate resuscitation of fluids. Objective This study aim was to assess the use of central venous catheter (CVC) and peripheral (external jugular) vein for low or moderate doses of noradrenaline regarding the outcome of septic shock among patients who are diagnosed with critical illnesses. Patients and methods This study is a prospective cohort study involving 120 patients according to sample size calculation with septic shock who were sorted randomly into two groups. Group I (the group involving the external jugular): 60 patients experienced septic shock and received low or moderate doses of noradrenaline in the external jugular vein. Group II (CVC group): 60 patients diagnosed with septic shock and received low or moderate noradrenaline doses in the CVC. Results Low or moderate doses of noradrenaline in the jugular line was associated with significantly higher blood pressure on day 7, and lower Sequential Organ Failure Assessment Score on days 5 and 7 than the CVC group. There was a difference that is statistically significant between ICU-involved duration of stay among the two involved study groups as it was found lower significantly among the jugular group. Conclusion Low or moderate doses of noradrenaline can be administered safely within the peripheral line (jugular) in patients with septic shock with minor complications causing a decrease in the duration of ICU stay.