利用全基因组数据鉴定当前巴西黄热病疫苗株的病毒种群和基因组稳定性

Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI:10.35259/isi.sact.2019_32592

Amanda Araújo Serrão Andrade, A. E. Soares, L. G. Almeida, C. Pestana, C. Aquino, Ana Teresa Ribeiro de Vaconcelos, M. Medeiros

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摘要

黄热病是一种由蚊媒黄热病黄病毒(YFV)引起的病毒性出血热。目前世界范围内用于预防黄热病的有两种独立衍生的YFV减毒疫苗株，分别是17DD (Bio-Manguinhos/ Fiocruz)和17D-204(世界卫生组织)。对疫苗库存的病毒基因组进行测序和组装，可以对疫苗株的活力和稳定性提供宝贵的见解，因为保持稳定的疫苗株对疫苗大规模生产至关重要。

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Identification of viral populations and genome stability of current Brazilian yellow fever vaccine strains using whole genome data

Introduction: Yellow fever is a viral hemorrhagic fever caused by the mosquito-borne yellow fever flavivirus (YFV). There are currently two YFV attenuated vaccine strains that are used worldwide to prevent yellow fever, which were independently derived, 17DD (Bio-Manguinhos/ Fiocruz) and 17D-204 (World Health Organization). Sequencing and assembling the virus genomes of vaccine stocks can provide invaluable insights into viability and stability of vaccine strains, as maintaining stable vaccine strains is essential for vaccine mass production.

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Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos

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