镜像神经元在自闭症谱系障碍中的影响的系统综述

C. Andrade, M. Pondé
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引用次数: 1

摘要

本研究的目的是对镜像神经元在自闭症病理生理中的作用的实验研究进行系统的回顾。四篇论文报道了自闭症患者的镜像神经元(MN)区域活动不足,这为MN作为ASD病因的理论提供了支持。三篇论文表明,在提议的活动中MN被激活,主张MN的非典型激活,但不一定是这些区域的失活。其中一篇文章报道,在自闭症患者中,只有部分MN系统或连接神经元的区域功能失调。对所选研究的分析表明,镜像神经元系统功能障碍与自闭症的主要症状(如社会认知缺陷、个体与社会环境的互动完全缺失或减少、模仿神经机制失败)之间存在相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A SYSTEMATIC REVIEW OF THE INFLUENCE OF MIRROR NEURONS IN AUTISM SPECTRUM DISORDERS
The objective of this study was to conduct a systematic review of experimental studies performed to assess the role of mirror neurons in the pathophysiology of autism. Four papers reported that areas of mirror neurons (MN) were under-active in autistic patients, giving weight to the theory of MN as a cause of ASD. Three papers indicated that MN were activated during the proposed activities, advocating atypical activation of MN, but not necessarily hypoactivation of these areas. One of the articles reported that only part of the MN system or just those areas of interconnected neurons are dysfunctional in autism. Analysis of the selected studies showed a correlation between dysfunction of the mirror neuron system and the main symptoms of autism such as deficits in social cognition, complete absence or a reduction in the individual’s interaction with his/her social environment and a failure in the neural mechanisms of imitation.
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