利用光通过量子点远程切换细胞活动

2010 International Conference on Optical MEMS and Nanophotonics Pub Date : 2010-12-17 DOI:10.1109/OMEMS.2010.5672180

K. Lugo, X. Miao, F. Rieke, Lih Y. Lin

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引用次数: 0

摘要

我们报道了CdTe量子点(QD)薄膜与LnCap(前列腺癌)细胞和CdSe量子点探针与皮质神经元的整合，以控制细胞活性。我们用光激发量子点来证明细胞活动的远程开关。膜片钳法记录了膜电位和离子电流的变化。在兴奋时，细胞表现出离子通道的激活和细胞膜的超极化。

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Remote switching of cellular activity using light through quantum dots

We report integration of CdTe quantum dot (QD) film with LnCap (prostate cancer) cell and CdSe QD probes with cortical neurons for control of cellular activity. We demonstrate the remote switching of cellular activity by exciting QDs with light. Changes in membrane potential and ionic currents are recorded using the patch-clamp method. Upon excitation, the cell shows activation of ion channels and hyperpolarization of the cell membrane.

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2010 International Conference on Optical MEMS and Nanophotonics

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